After a 2-0 victory over the Netherlands, the Czech Republic advances to the Euro 2020 quarter-finals.
The game was scoreless at halftime, but De Ligt was sent off on 55 minutes for handling the ball on the edge of the box, denying Schick a goal scoring opportunity.
The referee initially only gave the centre-back a yellow card, but VAR intervened and gave him a straight red.
Following a set piece, the Czech Republic pushed forward in numbers and were rewarded 13 minutes later when Holes fired them ahead.
Schick then scored his fourth goal of the tournament to give them a two-goal lead and seal the victory.